Antihyperlipidemic and Anti-Atherosclerosis Effectsīeta sitosterol is recommended for the prevention of different cardiovascular diseases 6 and the FDA has approved beta sitosterol for the treatment of hyperlipidemia 7. Apart from that small pilot study, there is still no long-term convincing result regarding the efficacy of beta sitosterol against alopecia or hair loss in men. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit. The results of this pilot study in the treatment of hair loss in men (androgenetic alopecia) 5 showed a positive response to treatment. Furthermore, the review authors added that more research into long‐term effects of beta‐sitosterols is needed 4. This 1999 Cochrane review found that beta‐sitosterol treatments were well tolerated and improved urinary symptoms and flow measures in men with mild to moderate benign prostatic hyperplasia (nonmalignant enlargement of the prostate). Three trials used non‐glucosidic B‐sitosterols and one utilized a preparation that contained 100% B‐sitosteryl‐B‐D‐glucoside. Beta sitosterol benefits Beta sitosterol prostateįive hundred nineteen men from four randomized, placebo‐controlled, double‐blind trials, (lasting 4 to 26 weeks) were assessed 4. Beta sitosterol could be obtained from different plants, but the total biosynthetic pathway, as well as its exact physiological and structural function in plants, have not been fully understood 2. Beta-sitosterol molecules are synthesized in plants whereas animals obtain them through diet 1. Beta-sitosterol glycoside, sitosterolin, is also present in serum, but in lower concentration 3. Beta sitosterol side effects What is beta sitosterolīeta-sitosterol (24-ethylcholesterol) is a phytosterol with a chemical structure similar to that of cholesterol 1, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. Beta-sitosterol is a natural micronutrient in higher plants and is found in the serum and tissues of healthy individuals at a concentration 800–1000 times lower than that of endogenous cholesterol 2.
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